Are Restless Legs Syndrome (RLS) symptoms keeping you from moving forward?

Start once-daily dosing with Horizant®¹

Are symptoms of moderate-to-severe primary RLS interrupting your night?⁸ You may want to talk to your healthcare provider about treatment options. Prepare for a conversation with your healthcare provider by learning more about RLS symptoms and treatments. Download our Doctor Discussion Guide to get the treatment conversation started.

Download the guide

Horizant® is a medication that you take just once daily. There’s no dose adjustment required. The dose you start on is the dose you stay on. However, be sure to tell your healthcare provider if you have kidney problems. Your dose may need to be adjusted.¹

Horizant® was studied in people with RLS. In these studies, the most common side effects were sleepiness and dizziness. About 30% of patients treated with Horizant® reported sleepiness throughout treatment. For the other patients, symptoms went away within 3 to 4 weeks.¹

Horizant® can help relieve RLS symptoms with one 600 mg daily dose^1-3

For treating moderate-to-severe primary RLS in adults, the recommended Horizant® dose is 600 mg. This dose should be taken once daily (usually around 5 PM) with food. The most common side effects of Horizant® in people with RLS are sleepiness and dizziness.¹

Remember to take Horizant® exactly as prescribed by your healthcare provider
Your healthcare provider will tell you how much Horizant® to take and when to take it
Take Horizant® tablets whole. Do not cut, crush, or chew your tablets¹
Tell your healthcare provider if you have kidney problems. Your dose may need to be adjusted¹

Key information you should know about taking Horizant® for RLS

Talk to your healthcare provider before starting or stopping Horizant® treatment¹

Be sure to tell your healthcare provider about other medications you are taking. This includes prescription and nonprescription medicines, vitamins, and herbal supplements. If you have kidney problems, ask your healthcare provider what dosing schedule is right for you. Do not stop taking Horizant® without talking to your healthcare provider ﬁrst. If you suddenly stop taking Horizant®, you may develop side effects.¹

Missing a dose of Horizant®¹

If you miss or forget to take a dose, just skip the missed dose. Take the next dose at the regular time. Do not take 2 doses at one time. If you take too much Horizant®, call your healthcare provider or immediately go to the nearest emergency room.¹

Horizant® is not the same as other gabapentin products¹

Horizant® should not be used in place of other gabapentin products. Do not take other gabapentin products while taking Horizant®.¹

Tips and resources to help you stay on track with treatment

Raise your relief level, lower your prescription costs

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NEXT: Why Horizant®?

Important Safety Information for HORIZANT® (gabapentin enacarbil) Extended-Release Tablets

INDICATIONS

HORIZANT® (gabapentin enacarbil) is a prescription medicine used to:

treat adults with moderate to severe primary Restless Legs Syndrome (RLS). HORIZANT is not for people who need to sleep during the daytime and stay awake at night.

manage pain from damaged nerves (postherpetic neuralgia) that follows healing of shingles (a painful rash that comes after a herpes zoster infection) in adults.

IMPORTANT SAFETY INFORMATION

Do not drive after taking your dose of HORIZANT until you know how it affects you, including the morning after you take it. Do not operate heavy machinery or do other dangerous activities until you know how HORIZANT affects you. HORIZANT can cause sleepiness, dizziness, slow thinking, and can affect your coordination. Ask your healthcare provider when it is okay to do these activities.

Do not take other medicines that make you sleepy or dizzy while taking HORIZANT without talking to your healthcare provider. Taking HORIZANT with these other medicines may make your sleepiness or dizziness worse.

HORIZANT may cause suicidal thoughts or actions in a very small number of people (about 1 in 500). Pay attention to any changes, especially sudden changes, in mood, behaviors, thoughts, or feelings. Call your healthcare provider right away if you have any of these symptoms, especially if they are new, worse, or worry you:

thoughts or actions about suicide, self-harm, or dying; attempt to commit suicide
new or worsening depression or anxiety; or feeling agitated
new or worse restlessness or panic attacks
new or worse trouble sleeping (insomnia); or irritability
acting aggressive, being angry, or violent; acting on dangerous impulses
an extreme increase in activity or talking (mania); other unusual changes in mood or behavior

Serious breathing problems. Serious breathing problems can occur when HORIZANT is taken with other medicines that can cause severe sleepiness or decreased awareness, or when it is taken by someone who already has breathing problems. Watch for increased sleepiness or decreased breathing when starting HORIZANT or when the dose is increased. Get help right away if breathing problems occur.

Do not stop taking HORIZANT without first talking to your healthcare provider. Suicidal thoughts or actions can be caused by things other than medicines. If you have these thoughts or actions, your healthcare provider may check for other causes.

HORIZANT may cause a serious or life-threatening allergic reaction that may affect your skin or other parts of your body such as your liver or blood cells. You may or may not have a rash with these types of reactions. Call a healthcare provider right away if you have any of the following symptoms: skin rash, hives, fever, swollen glands that do not go away, swelling of your lips or tongue, yellowing of your skin or eyes, unusual bruising or bleeding, severe fatigue or weakness, unexpected severe muscle pain, or frequent infections. These symptoms may be the first signs of a serious reaction. A healthcare provider should examine you to decide if you should continue taking HORIZANT.

HORIZANT is not the same medicine as gabapentin [for example, NEURONTIN® (gabapentin) and GRALISE® (gabapentin)]. HORIZANT should not be used in their place. Do not take these or other gabapentin products while taking HORIZANT.

Before taking HORIZANT, tell your healthcare provider if you:

have or have had kidney problems or are on hemodialysis
have or have had depression, mood problems, or suicidal thoughts or behavior
have or have had seizures
have a history of drug abuse
have any other medical conditions
are pregnant or plan to become pregnant. It is not known if HORIZANT will harm your unborn baby. Talk to your healthcare provider if you are pregnant or plan to become pregnant while taking HORIZANT. You and your healthcare provider will decide if you should take HORIZANT while you are pregnant
are breastfeeding or plan to breastfeed. Your body turns HORIZANT into another drug (gabapentin) that passes into your milk. It is not known if this can harm your baby. You and your healthcare provider should decide if you will take HORIZANT or breastfeed
drink alcohol

Do not drink alcohol while taking HORIZANT because it may increase the risk of side effects.

Tell your healthcare provider about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. Taking HORIZANT with certain other medicines can cause side effects or affect how well they work. Do not start or stop other medicines without talking to your healthcare provider.

Do not stop taking HORIZANT without talking to your healthcare provider first. If you stop taking HORIZANT suddenly, you may develop side effects.

The most common side effects of HORIZANT include dizziness, sleepiness, and headache. Tell your healthcare provider about any side effect that bothers you or does not go away. These are not all the possible side effects of HORIZANT. For more information, ask your healthcare provider or pharmacist.

To report a possible side effect, contact Azurity Pharmaceuticals, Inc by email or phone at aereports@azurity.com (Adverse Event Report Form)/1-800-461-7449, or FDA at 1-800-FDA-1088 or www.fda.gov/MedWatch.

For more information, ask your healthcare provider or pharmacist, or consult the full Prescribing Information.

Start once-daily dosing with Horizant®¹

Horizant® can help relieve the symptoms of moderate-to-severe primary RLS^1,3

Horizant® can help relieve RLS symptoms with one 600 mg daily dose^1-3

Key information you should know about taking Horizant® for RLS

Talk to your healthcare provider before starting or stopping Horizant® treatment¹

Missing a dose of Horizant®¹

Horizant® is not the same as other gabapentin products¹

Tips and resources to help you stay on track with treatment

Raise your relief level, lower your prescription costs

Important Safety Information for HORIZANT® (gabapentin enacarbil) Extended-Release Tablets

INDICATIONS

IMPORTANT SAFETY INFORMATION

Copay Savings Card program COMING SOON!

Start once-daily dosing with Horizant®1

Horizant® can help relieve the symptoms of moderate-to-severe primary RLS1,3

Horizant® can help relieve RLS symptoms with one 600 mg daily dose1-3

Key information you should know about taking Horizant® for RLS

Talk to your healthcare provider before starting or stopping Horizant® treatment1

Missing a dose of Horizant®1

Horizant® is not the same as other gabapentin products1

Tips and resources to help you stay on track with treatment

Raise your relief level, lower your prescription costs

Important Safety Information for HORIZANT® (gabapentin enacarbil) Extended-Release Tablets

INDICATIONS

IMPORTANT SAFETY INFORMATION

Start once-daily dosing with Horizant®¹

Horizant® can help relieve the symptoms of moderate-to-severe primary RLS^1,3

Horizant® can help relieve RLS symptoms with one 600 mg daily dose^1-3

Talk to your healthcare provider before starting or stopping Horizant® treatment¹

Missing a dose of Horizant®¹

Horizant® is not the same as other gabapentin products¹